Hafler Laboratory Template

Hafler Laboratory Publications 2004-2000

Anderson, D. E., K. D. Bieganowska, et al. (2000). "Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population." Nat Med 6 (2): 211-4. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10655112

Anderson, D. E. and D. A. Hafler (2001). "Immune tolerance and the nervous system." Adv Exp Med Biol 490: 79-98. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11505978

Baecher-Allan, C., J. A. Brown, et al. (2001). "CD4+CD25high regulatory cells in human peripheral blood." J Immunol 167 (3): 1245-53. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11466340

Baecher-Allan, C., J. A. Brown, et al. (2003). "CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo." Novartis Found Symp 252: 67-88; discussion 88-91, 106-14. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14609213

Baecher-Allan, C. and D. A. Hafler (2004). "Suppressor T cells in human diseases." J Exp Med 200 (3): 273-6. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15280423

Baecher-Allan, C., V. Viglietta, et al. (2002). "Inhibition of human CD4(+)CD25(+high) regulatory T cell function." J Immunol 169 (11): 6210-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12444126

Baecher-Allan, C., V. Viglietta, et al. (2004). "Human CD4+CD25+ regulatory T cells." Semin Immunol 16 (2): 89-98. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15036232

Bar-Or, A., E. M. Oliveira, et al. (2001). "Immunological memory: contribution of memory B cells expressing costimulatory molecules in the resting state." J Immunol 167 (10): 5669-77. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11698439

Bourcier, K. D., D. G. Lim, et al. (2001). "Conserved CDR3 regions in T-cell receptor (TCR) CD8(+) T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: relationship of T-cell fine specificity and major histocompatibility complex/peptide/TCR crystal structure." J Virol 75 (20): 9836-43. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11559817

Buckle, G. J., P. Hollsberg, et al. (2003). "Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin." Neurology 60 (4): 702-5. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12601116

Cai, G., A. Karni, et al. (2004). "PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells." Cell Immunol 230 (2): 89-98. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15598424

Cao, D., V. Malmstrom, et al. (2003). "Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis." Eur J Immunol 33 (1): 215-23. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12594850

De Jager, P. L. and D. A. Hafler (2004). "Gene expression profiling in MS: what is the clinical relevance?" Lancet Neurol 3 (5): 269. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15099539

De Jager, P. L., E. C. Walsh, et al. (2004). "Re: GAMES issue study: Are international genetic consortia functional?" J Neuroimmunol 153 (1-2): 5-6. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15334748

Duda, P. W., J. I. Krieger, et al. (2000). "Human and murine CD4 T cell reactivity to a complex antigen: recognition of the synthetic random polypeptide glatiramer acetate." J Immunol 165 (12): 7300-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11120865

Duda, P. W., M. C. Schmied, et al. (2000). "Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis." J Clin Invest 105 (7): 967-76. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10749576

Ellmerich, S., K. Takacs, et al. (2004). "Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis." Eur J Immunol 34 (7): 1839-48. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15214032

Gausling, R., C. Trollmo, et al. (2001). "Decreases in interleukin-4 secretion by invariant CD4(-)CD8(-)V alpha 24J alpha Q T cells in peripheral blood of patientswith relapsing-remitting multiple sclerosis." Clin Immunol 98 (1): 11-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11141321

Hafler, D. A. (2002). "Degeneracy, as opposed to specificity, in immunotherapy." J Clin Invest 109 (5): 581-4. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11877465

Hafler, D. A. (2004). "Multiple sclerosis." J Clin Invest 113 (6): 788-94. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15067307

Harrison, L. C. and D. A. Hafler (2000). "Antigen-specific therapy for autoimmune disease." Curr Opin Immunol 12 (6): 704-11. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11102776

Hunter, S. F. and D. A. Hafler (2000). "Ubiquitous pathogens: links between infection and autoimmunity in MS?" Neurology 55 (2): 164-5. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10908883

Kantarci, O. H., D. D. Hebrink, et al. (2003). "CTLA4 is associated with susceptibility to multiple sclerosis." J Neuroimmunol 134 (1-2): 133-41. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12507781

Khademi, M., Z. Illes, et al. (2004). "T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis." J Immunol 172 (11): 7169-76. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15153541

Kiefer, R., F. Dangond, et al. (2000). "Enhanced B7 costimulatory molecule expression in inflammatory human sural nerve biopsies." J Neurol Neurosurg Psychiatry 69 (3): 362-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10945811

Kipp, B., A. Bar-Or, et al. (2000). "A novel population of B7-1+ T cells producing intracellular IL-4 is decreased in patients with multiple sclerosis." Eur J Immunol 30 (7): 2092-100. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10940899

Lim, D. G., K. Bieganowska Bourcier, et al. (2000). "Examination of CD8+ T cell function in humans using MHC class I tetramers: similar cytotoxicity but variable proliferation and cytokine production among different clonal CD8+ T cells specific to a single viral epitope." J Immunol 165 (11): 6214-20. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11086055

Lim, D. G., P. Hollsberg, et al. (2002). "Strength of prior stimuli determines the magnitude of secondary responsiveness in CD8+ T cells." Cell Immunol 217 (1-2): 36-46. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12425999

Lim, D. G., J. M. Slavik, et al. (2003). "Allelic variation of MHC structure alters peptide ligands to induce atypical partial agonistic CD8+ T cell function." J Exp Med 198 (1): 99-109. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12847139

Meyer, A. L., C. Trollmo, et al. (2000). "Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers." Proc Natl Acad Sci U S A 97 (21): 11433-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11005833

Mycko, M. P., H. Waldner, et al. (2004). "Cross-reactive TCR responses to self antigens presented by different MHC class II molecules." J Immunol 173 (3): 1689-98. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15265898

O'Connor, K. C., A. Bar-Or, et al. (2001). "The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis." J Clin Immunol 21 (2): 81-92. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11332657

O'Connor, K. C., T. Chitnis, et al. (2003). "Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions." J Neuroimmunol 136 (1-2): 140-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12620653

Ohashi, T., M. Yukitake, et al. (2001). "In vitro evidence that immunuaffinity-purified MOG contains immunogenic quantities of contaminating mouse IgG; techniques for producing Ig-free MOG." J Neuroimmunol 118 (2): 194-202. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11498254

Oliveira, E. M., A. Bar-Or, et al. (2003). "CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls." J Autoimmun 20 (1): 71-81. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12604314

Orban, T., S. C. Kent, et al. (2001). "Heterophile antibodies indicate progression of autoimmunity in human type 1 diabetes mellitus before clinical onset." Autoimmunity 34 (4): 247-64. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11905851

Patterson, N., N. Hattangadi, et al. (2004). "Methods for high-density admixture mapping of disease genes." Am J Hum Genet 74 (5): 979-1000. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15088269

Sawcer, S. J., M. Maranian, et al. (2004). "Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping." Hum Mol Genet 13 (17): 1943-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15238506

Schmied, M., P. W. Duda, et al. (2003). "In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis." Clin Immunol 106 (3): 163-74. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12706402

Slavik, J. M., D. G. Lim, et al. (2001). "Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytes." J Immunol 166 (5): 3201-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11207273

Slavik, J. M., D. G. Lim, et al. (2004). "Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity." J Biol Chem 279 (2): 910-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14573608

Smith, M. W., N. Patterson, et al. (2004). "A high-density admixture map for disease gene discovery in african americans." Am J Hum Genet 74 (5): 1001-13. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15088270

Trollmo, C., A. L. Meyer, et al. (2001). "Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1 alpha L is a partial agonist for outer surface protein A-reactive T cells." J Immunol 166 (8): 5286-91. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11290815

Viglietta, V., C. Baecher-Allan, et al. (2004). "Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis." J Exp Med 199 (7): 971-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15067033

Viglietta, V., S. C. Kent, et al. (2002). "GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes." J Clin Invest 109 (7): 895-903. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11927616

Vijayakrishnan, L., J. M. Slavik, et al. (2004). "An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells." Immunity 20 (5): 563-75. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15142525

Walsh, E. C., S. Guschwan-McMahon, et al. (2003). "Genetic analysis of multiple sclerosis." J Autoimmun 21 (2): 111-6. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12935779

Wilson, S. B., S. C. Kent, et al. (2000). "Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes." Proc Natl Acad Sci U S A 97 (13): 7411-6. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10840051