Hafler Laboratory Publications 1995-1999
Anderson, D. E., L. J. Ausubel, et al. (1997). "Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones." J Immunol 159 (4): 1669-75. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9257827
Anderson, D. E., A. H. Sharpe, et al. (1999). "The B7-CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system." Curr Opin Immunol 11 (6): 677-83. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10631554
Ausubel, L. J., K. D. Bieganowska, et al. (1999). "Cross-reactivity of T-cell clones specific for altered peptide ligands of myelin basic protein." Cell Immunol 193 (1): 99-107. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10202117
Ausubel, L. J., J. I. Krieger, et al. (1997). "Changes in cytokine secretion induced by altered peptide ligands of myelin basic protein peptide 85-99." J Immunol 159 (5): 2502-12. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9278344
Ausubel, L. J., C. K. Kwan, et al. (1996). "Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones." Proc Natl Acad Sci U S A 93 (26): 15317-22. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8986809
Balashov, K. E., S. J. Khoury, et al. (1995). "Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis." J Clin Invest 95 (6): 2711-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7769110
Balashov, K. E., D. R. Smith, et al. (1997). "Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand." Proc Natl Acad Sci U S A 94 (2): 599-603. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9012830
Bar-Or, A., E. M. Oliveira, et al. (1999). "Molecular pathogenesis of multiple sclerosis." J Neuroimmunol 100 (1-2): 252-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10695735
Bieganowska, K., P. Hollsberg, et al. (1999). "Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy." J Immunol 162 (3): 1765-71. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9973440
Bieganowska, K. D., L. J. Ausubel, et al. (1997). "Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease." J Exp Med 185 (9): 1585-94. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9151896
Buckle, G. J., D. A. Hafler, et al. (1996). "HTLV-I-induced T-cell activation." J Acquir Immune Defic Syndr Hum Retrovirol 13 Suppl 1: S107-13. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8797712
Dangond, F., J. S. Daza, et al. (1995). "Tropical spastic paraparesis on the Caribbean coast of Colombia." Am J Trop Med Hyg 52 (2): 155-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7872443
Dangond, F., D. A. Hafler, et al. (1998). "Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells." Biochem Biophys Res Commun 242 (3): 648-52. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9464271
Dangond, F., A. Windhagen, et al. (1997). "Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity." J Neuroimmunol 76 (1-2): 132-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9184642
Dressel, A., J. L. Chin, et al. (1997). "Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands." J Immunol 159 (10): 4943-51. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9366420
Flavell, R. A. and D. A. Hafler (1999). "Autoimmunity. What is the turning point?" Curr Opin Immunol 11 (6): 635-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10631547
Fukaura, H., S. C. Kent, et al. (1996). "Antigen-specific TGF-beta1 secretion with bovine myelin oral tolerization in multiple sclerosis." Ann N Y Acad Sci 778: 251-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8610978
Fukaura, H., S. C. Kent, et al. (1996). "Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients." J Clin Invest 98 (1): 70-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8690806
Greenfield, E. A., E. Howard, et al. (1997). "B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors." J Immunol 158 (5): 2025-34. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9036945
Hafler, D. A. (1999). "The distinction blurs between an autoimmune versus microbial hypothesis in multiple sclerosis." J Clin Invest 104 (5): 527-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10487765
Hafler, D. A. and R. Flavell (1996). "Autoimmunity. How to know thy self." Curr Opin Immunol 8 (6): 805-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8994859
Hafler, D. A., S. C. Kent, et al. (1997). "Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T cells in patients with multiple sclerosis." Ann N Y Acad Sci 835: 120-31. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9616767
Hafler, D. A., M. G. Saadeh, et al. (1996). "TCR usage in human and experimental demyelinating disease." Immunol Today 17 (4): 152-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8871344
Hafler, D. A. and H. L. Weiner (1995). "Antigen specific therapies for the treatment of autoimmune diseases." Agents Actions Suppl 47: 59-77. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7785504
Hafler, D. A. and H. L. Weiner (1995). "Antigen-specific immunosuppression: oral tolerance for the treatment of autoimmune disease." Chem Immunol 60: 126-49. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7857525
Hafler, D. A. and H. L. Weiner (1995). "Antigen-specific therapies for the treatment of autoimmune diseases." Springer Semin Immunopathol 17 (1): 61-76. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7482227
Hafler, D. A. and H. L. Weiner (1995). "Immunologic mechanisms and therapy in multiple sclerosis." Immunol Rev 144: 75-107. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7590822
Hohol, M. J., S. J. Khoury, et al. (1996). "Three-year open protocol continuation study of oral tolerization with myelin antigens in multiple sclerosis and design of a phase III pivotal trial." Ann N Y Acad Sci 778: 243-50. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8610977
Hohol, M. J., M. J. Olek, et al. (1999). "Treatment of progressive multiple sclerosis with pulse cyclophosphamide/methylprednisolone: response to therapy is linked to the duration of progressive disease." Mult Scler 5 (6): 403-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10618696
Hollsberg, P., V. Batra, et al. (1996). "Induction of anergy in CD8 T cells by B cell presentation of antigen." J Immunol 157 (12): 5269-76. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8955172
Hollsberg, P. and D. A. Hafler (1995). "What is the pathogenesis of human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis?" Ann Neurol 37 (2): 143-5. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7847855
Hollsberg, P., C. Scholz, et al. (1997). "Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4." J Immunol 159 (10): 4799-805. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9366404
Hollsberg, P., W. E. Weber, et al. (1995). "Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand." Proc Natl Acad Sci U S A 92 (9): 4036-40. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7732026
Kent, S. C., H. Fukaura, et al. (1997). "Oral administration of myelin induces antigen-specific TGF-beta 1-secreting T cells in multiple sclerosis patients." Ann N Y Acad Sci 815: 412-22. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9186687
Kent, S. C., D. A. Hafler, et al. (1999). "Noncanonical Valpha24JalphaQ T cells with conservative alpha chain CDR3 region amino acid substitutions are restricted by CD1d." Hum Immunol 60 (11): 1080-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10600006
Mandelboim, O., S. Kent, et al. (1998). "Natural killer activating receptors trigger interferon gamma secretion from T cells and natural killer cells." Proc Natl Acad Sci U S A 95 (7): 3798-803. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9520447
Markovic-Plese, S., H. Fukaura, et al. (1995). "T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans." J Immunol 155 (2): 982-92. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7541828
Martin, R., N. H. Ruddle, et al. (1998). "T helper cell differentiation in multiple sclerosis and autoimmunity." Immunol Today 19 (11): 495-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9818541
Matsui, M., D. A. Hafler, et al. (1996). "Pilot study of oral tolerance to keyhole limpet hemocyanin in humans: down-regulation of KLH-reactive precursor-cell frequency." Ann N Y Acad Sci 778: 398-404. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8611003
McLaurin, J. A., D. A. Hafler, et al. (1995). "Reactivity of normal T-cell lines to MBP isolated from normal and multiple sclerosis white matter." J Neurol Sci 128 (2): 205-11. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7537795
Milner, J. D., S. C. Kent, et al. (1999). "Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone." J Immunol 163 (5): 2522-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10452989
Nussenblatt, R. B., I. Gery, et al. (1997). "Treatment of uveitis by oral administration of retinal antigens: results of a phase I/II randomized masked trial." Am J Ophthalmol 123 (5): 583-92. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9152063
Pohl-Koppe, A., K. E. Balashov, et al. (1998). "Identification of a T cell subset capable of both IFN-gamma and IL-10 secretion in patients with chronic Borrelia burgdorferi infection." J Immunol 160 (4): 1804-10. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9469440
Pohl-Koppe, A., S. K. Burchett, et al. (1998). "Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitis." J Neuroimmunol 91 (1-2): 19-27. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9846815
Pohl-Koppe, A., E. L. Logigian, et al. (1999). "Cross-reactivity of Borrelia burgdorferi and myelin basic protein-specific T cells is not observed in borrelial encephalomyelitis." Cell Immunol 194 (1): 118-23. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10357888
Richardson, J. H., P. Hollsberg, et al. (1997). "Variable immortalizing potential and frequent virus latency in blood-derived T-cell clones infected with human T-cell leukemia virus type I." Blood 89 (9): 3303-14. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9129036
Rothenberg, M. E., W. E. Weber, et al. (1996). "Cytotoxic gamma delta I lymphocytes associated with an Epstein-Barr virus-induced posttransplantation lymphoproliferative disorder." Clin Immunol Immunopathol 80 (3 Pt 1): 266-72. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8811046
Scholz, C., G. J. Freeman, et al. (1996). "Activation of human T cell lymphotropic virus type I-infected T cells is independent of B7 costimulation." J Immunol 157 (7): 2932-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8816399
Scholz, C., D. A. Hafler, et al. (1996). "Downregulation of IL-10 secretion and enhanced antigen-presenting abilities following HTLV-I infection of T cells." J Neurosci Res 45 (6): 786-94. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8892090
Scholz, C., K. T. Patton, et al. (1998). "Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation." J Immunol 160 (3): 1532-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9570577
Semana, G., R. Gausling, et al. (1999). "T cell autoreactivity to proinsulin epitopes in diabetic patients and healthy subjects." J Autoimmun 12 (4): 259-67. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10330297
She, J. X., T. M. Ellis, et al. (1999). "Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes." Proc Natl Acad Sci U S A 96 (14): 8116-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10393957
Smith, D., G. J. Buckle, et al. (1999). "HTLV-I-infected T cells evade the antiproliferative action of IFN-beta." Virology 257 (2): 314-21. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10329542
Smith, D. R., K. E. Balashov, et al. (1997). "Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: increased interleukin-4 production and associated eosinophilia." Ann Neurol 42 (3): 313-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9307252
Stinissen, P., C. Vandevyver, et al. (1995). "Increased frequency of gamma delta T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity, and T cell receptor V gene rearrangements." J Immunol 154 (9): 4883-94. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7722338
Takashima, H., D. R. Smith, et al. (1998). "Pulse cyclophosphamide plus methylprednisolone induces myelin-antigen-specific IL-4-secreting T cells in multiple sclerosis patients." Clin Immunol Immunopathol 88 (1): 28-34. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9683547
Weiner, H. L., M. J. Hohol, et al. (1995). "Therapy for multiple sclerosis." Neurol Clin 13 (1): 173-96. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7739502
Wilson, S. B., S. C. Kent, et al. (1998). "Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes." Nature 391 (6663): 177-81. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9428763
Windhagen, A., D. E. Anderson, et al. (1998). "Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis." J Neuroimmunol 91 (1-2): 1-9. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9846813
Windhagen, A., D. E. Anderson, et al. (1996). "IL-12 induces human T cells secreting IL-10 with IFN-gamma." J Immunol 157 (3): 1127-31. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8757617
Windhagen, A., J. Newcombe, et al. (1995). "Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions." J Exp Med 182 (6): 1985-96. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7500044
Windhagen, A., L. B. Nicholson, et al. (1996). "Role of Th1 and Th2 cells in neurologic disorders." Chem Immunol 63: 171-86. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8934837
Windhagen, A., C. Scholz, et al. (1995). "Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand." Immunity 2 (4): 373-80. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7536622
Wucherpfennig, K. W. and D. A. Hafler (1995). "A review of T-cell receptors in multiple sclerosis: clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide." Ann N Y Acad Sci 756: 241-58. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7544075
Wucherpfennig, K. W., D. A. Hafler, et al. (1995). "Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes." Proc Natl Acad Sci U S A 92 (19): 8896-900. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7568039