Fellow in Neurology

Center for Neurologic Diseases
Brigham and Women's Hospital
Harvard Medical School, NRB641
77 Avenue Louis Pasteur
Boston, MA 02115

Tel: (617) 525-5330
Fax: (617) 525-5333

Email:whastings@rics.bwh.harvard.edu

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Education & Training:

• University of Southern Maine, Portland, Maine B.S. 1997 Biology
• University of Southern Maine, Portland, Maine M.S. 1999 Applied Immunology
• Boston University School of Medicine, Boston MA Ph.D. 2005 Immunology

Research & Professional Experience:

• 1997-1999 Graduate Student, Department of Applied Medical Sciences, University of Southern Maine
• 1999-2005 Ph.D. Candidate, Department of Microbiology/Immunology Training Program, Boston University School of Medicine
• 2005 Postdoctoral Fellow, Immunobiology Unit, Department of Medicine, Boston University School of Medicine
• 2005- Research Fellow, Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Boston, MA
• 2005- Research Fellow, Department of Neurology, Harvard Medical School, Boston, MA

Research Interests:

Factors that regulate the development of human Th17 cells.
The role of TIM-3 in both normal and autoimmune human T cell responses.

Publications:

Fischer GM, Solt LA, Hastings WD, Yang K, Gerstein RM, Nikolajczyk BS, Clarke SH, Rothstein TL.  Peritoneal and splenic B-1 cells differ in terms of transcriptional and proliferative features that separate peritoneal B-1 cells from splenic B-2 cells.  Cell Immunol  213:62;(2001).

Tumang JR, Negm RS, Solt LA, Schneider TJ, Colarusso TP, Hastings WD, Woodland RT, Rothstein TL. BCR engagement induces Fas-resistance in primary B cells in the absence of functional Btk.  J Immunol 168:2712;(2002).

Welner R, Hastings WD, Hill BL, Pelsue SC.  Hyperactivation and proliferation of lymphocytes from the spleens of flaky skin (fsn) mutant mice.  Autoimmunity 37(3):227-35;(2004).

Tumang JR, Hastings WD, Bai C, Rothstein TL. Peritoneal and splenic B-1 cells are separable by phenotypic, functional and transcriptomic characteristics.  Eur. J. Immunol 34(8):2158;(2004)

Foote LC, Evans JW, Cifuni JM, Siracusa MC, Monteforte GM, McCole JL, D’Orazio CC, Hastings WD, Rothstein TL. Interleukin-4 produces a breakdown in tolerance in vivo with autoantibody formation and autoimmune disease.  Autoimmunity 37(8):569-77(2004).

Hastings WD, Tumang JR, Behrens TW, Rothstein TL. Peritoneal B-2 cells comprise a distinct B-2 cell population with B-1b-like characteristics. Eur. J. Immunol. 36: 1114-23; (2006).

Hastings WD, Tumang JR, Gurdak S, Rothstein TL. CD5+/Mac-1- peritoneal B cells: a novel B cell subset that exhibits characteristics of B-1 cells. Immonol. Lett. 105: 90-96; (2006).

Anderson AC, Anderson DE, Bregoli L, Hastings WD, Kassam N, Lei C, Chandwaskar R, Karman J, Su EW, Hirashima M, Bruce JN, Kane LP, Kuchroo VK, Hafler DA. Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune system cells. Science 318:1141-43; (2007).

Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK, Hafler DA. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature. 454(7202): 350-2; (2008)