Fellow in Neurology

Center for Neurologic Diseases
Brigham and Women's Hospital
Harvard Medical School, NRB641
77 Avenue Louis Pasteur
Boston, MA 02115

Tel: (617) 525-5330
Fax: (617) 525-5333

Email:lmaier@rics.bwh.harvard.edu

Education and training.

Anglia Ruskin University B.Sc. 1998-2001 Biomedical Science

University of Cambridge Ph.D. 2001-2005 Medical Genetics

Positions and Honors.

2000-2001: Department of Clinical Biochemistry, University of Cambridge

2001: UK Institute of Biomedical Science President’s Prize

2001-2005: Wellcome Trust Prize Studentship: Graduate student, JDRF/WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK. Thesis entitled “Genetic and functional studies of mechanisms in type 1 diabetes” under supervision of Prof. John Todd

2005-2006: Postdoctoral fellow at the JDRF/WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK. Advisor: Prof. Linda Wicker

2006-present: Juvenile Diabetes Research Foundation Postdoctoral Fellowship: Center for Neurologic Disease. Postdoctoral Fellow

Selected peer-reviewed publications (in chronological order).

Maier, L.M., Twells, R.C., Howson, J.M., Lam, A.C., Clayton, D.G., Smyth, D.J., Savage, D., Carson, D., Patterson, C.C., Smink, L.J., Walker, N.M., Burren, O.S., Nutland, S., Rance, H., Tuomilehto-Wolf, E., Tuomilehto, J., Guja, C., Ionescu-Tirgoviste, C., Undlien, D.E., Ronningen, K.S., Cucca, F., Todd, J.A. (2003) Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene. Genes and Immunity 4(7):469-75

Downie, M.M., Sanders, D.A., Maier, L.M., Stock, D.M., Kealey, T. (2004) Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. British Journal of Dermatology 151(4):766-75.

Smyth, D.J., Cooper, J.D., Collins, J.E., Heward, J.M., Franklyn, J.A., Howson, J.M.M., Vella, A., Nutland, S., Rance, H.E., Maier, L., Barratt, B.J., Guja, C., Ionescu-Tîrgoviste, C., Savage, D.A., Dunger, D.B., Widmer, B., Strachan, D.P., Ring, S.M., Walker, N., Clayton, D.G., Twells, R.C.J., Gough, S.C.L., Todd, J.A. (2004) Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/ PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes 53(11):3020-3.

Maier, L.M., Chapman, J., Howson, J.M., Clayton, D.G., Pask, R., Strachan, D.P., McArdle, W.L., Twells, R.C., Todd, J.A. No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes. (2005) American Journal of Human Genetics 76(3):517-21

Maier, L.M., Smyth, D.J., Vella, A., Payne, F., Cooper, J.D., Pask, R., Lowe, C., Hulme, J., Smink, L.J., Fraser, H., Moule, C., Hunter, K.M., Chamberlain, G., Walker, N., Nutland, S., Undlien, D.E., Ronningen, K.S., Guja, C., Ionescu-

Tirgoviste, C., Savage, D.A., Strachan, D.P., Peterson, L.B., Todd, J.A., Wicker, L.S., Twells, R.C. (2005) Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes. BioMed Central Genetics 18;6(1):9

Maier, L.M., Cooper, J.D., Walker, N., Smyth, D.J., Todd, J.A. Comment to: Biason-Lauber A, Boehm B, Lang-Muritano M. et al. (2005) Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48:900-905

Maier, L.M. and Wicker, L.S.W. Genetics of Type 1 Diabetes. (2005) Current Opinion in Immunology 7(6):601-608

Clayton, D.G., Walker, N.M., Smyth, D.J., Pask, R., Cooper, J.D., Maier, L.M., Smink, L.J., Lam, A.C., Ovington, N.R., Rance, H., Nutland, S., Howson, J.M.M., Faham, M., Moorhead, M., Jones, H.B., Falkowski, M., Hardenbol, P., Willis,

T.D. & Todd, J.A. (2005) Population structure, differential bias, and genomic control in a large scale, case-control association study. Nature Genetics 37(11):1243-1246

Smyth DJ, Howson JM, Payne F, Maier LM, Bailey R, Holland K, Lowe CE, Cooper JD, Hulme JS, Vella A, Dahlman I, Lam AC, Nutland S, Walker NM, Twells RC, Todd JA (2006).  Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases. BMC Med Genet. 7:20.

Maier, L.M., Howson, J.M.M., Walke, N., Spicket, G.P., Jones, R.W., Ring, S.M., McArdle, W.L., Lowe, C.E., Bailey, R., Payne, F., Todd, J.A., Strachan, D.P. (2005) Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes. The Journal of Allergy and Clinical Immunology. 117(6):1306-13

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