Hafler Laboratory Home

The Hafler Laboratory of Molecular Immunology focuses on understanding fundamental immunology and the pathogenesis of human autoimmune disease.

Specifically our research goals are as follows:

• Characterization of regulatory T cells and their role in autoimmune disease.
• Identification of B cell antigens relevant to multiple sclerosis.
• Characterization of TCR signaling cascades.
• Characterization of the role of co-stimulatory molecules in autoimmune disease.

Details can be found by clicking the 'Our Research' button the above.

Dr. Hafler and colleagues at The International Multiple Sclerosis Genetics Consortium (IMSGC) have identified two new genetic variations associated with MS, completing the largest replicated whole genome scan for multiple sclerosis to date. The publication appearing in the New England Journal of Medicine can be seen here. More information on this major finding can be found in our publications page.

Several major print media outlets reported the story. They include: The New York Times-link, Reuters-link and Time Magazine-link. In addition the BBC interviewed-link Dr. Hafler on their radio network. Click any of the links to read or hear the stories